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A Mixed Finite Element Method to Solve the EEG Forward Problem

机译:一种求解脑电前向问题的混合有限元方法

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摘要

Finite element methods have been shown to achieve high accuracies innumerically solving the EEG forward problem and they enable the realisticmodeling of complex geometries and important conductive features such asanisotropic conductivities. To date, most of the presented approaches rely onthe same underlying formulation, the continuous Galerkin (CG)-FEM. In thisarticle, a novel approach to solve the EEG forward problem based on a mixedfinite element method (Mixed-FEM) is introduced. To obtain the Mixed-FEMformulation, the electric current is introduced as an additional unknownbesides the electric potential. As a consequence of this derivation, theMixed-FEM is, by construction, current preserving, in contrast to the CG-FEM.Consequently, a higher simulation accuracy can be achieved in certainscenarios, e.g., when the diameter of thin insulating structures, such as theskull, is in the range of the mesh resolution. A theoretical derivation of the Mixed-FEM approach for EEG forwardsimulations is presented, and the algorithms implemented for solving theresulting equation systems are described. Subsequently, first evaluations inboth sphere and realistic head models are presented, and the results arecompared to previously introduced CG-FEM approaches. Additional visualizationsare shown to illustrate the current preserving property of the Mixed-FEM. Based on these results, it is concluded that the newly presented Mixed-FEMcan at least complement and in some scenarios even outperform the establishedCG-FEM approaches, which motivates a further evaluation of the Mixed-FEM forapplications in bioelectromagnetism.
机译:有限元方法已被证明可以无数次地解决EEG正向问题,并且可以实现复杂几何形状和重要导电特性(如各向异性电导率)的真实建模。迄今为止,大多数提出的方法都依赖于相同的基本公式,即连续Galerkin(CG)-FEM。本文介绍了一种基于混合有限元方法(Mixed-FEM)的解决脑电正向问题的新方法。为了获得混合有限元公式,除了电位以外,还引入了电流作为其他未知因素。作为这种推导的结果,与CG-FEM相比,混合FEM通过构造可保持电流。因此,在某些情况下(例如当薄绝缘结构的直径例如头骨,在网格分辨率的范围内。提出了用于脑电信号前向仿真的混合有限元方法的理论推导,并描述了用于求解结果方程组的算法。随后,提出了对球体模型和真实头部模型的首次评估,并将结果与​​先前介绍的CG-FEM方法进行了比较。显示了其他可视化效果,以说明Mixed-FEM的当前保留特性。基于这些结果,得出的结论是,新提出的混合有限元方法至少可以补充甚至在某些情况下优于已建立的CG-FEM方法,这激发了对混合有限元方法在生物电磁学中的应用的进一步评估。

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